Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | HCK | P08631 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | APOB | P04114 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6549725 | 0.93 | MAPT (0.55) | MAPTKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL6550946 | 0.90 | MAPT (0.52) | MAPTKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL6698710 | 0.88 | MAPT (0.56) | MAPTKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL6697823 | 0.88 | MAPT (0.53) | MAPTKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL6695066 | 0.82 | MTTP (0.61) | MAPTKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL6699496 | 0.81 | RXFP1 (0.52) | MAPTSMN1; SMN2ALDH1A1KDM4EAPOB | |
| SCHEMBL24989582 | 0.80 | MAPT (0.60) | MAPTKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL11960760 | 0.79 | KMT2A (0.71) | MAPTKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL7258612 | 0.79 | MAPT (0.51) | MAPTKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL6496929 | 0.79 | MAPT (0.57) | MAPTKMT2AMEN1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383753-A1 | PIPERAZINE-BENZAMIDE DERIVATIVES USEFUL AS APOB-100 AND/OR MTP INHIBITOR | GLAXO GROUP LIMITED (GB) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002083658-A1 | PIPERAZINE-BENZAMIDE DERIVATIVES USEFUL AS APOB-100 AND/OR MTP INHIBITOR | GLAXO GROUP LIMITED (GB) | 2002-10-24 | — | — | WO | disclosed |