Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 16/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.58 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.55 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.55 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.55 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.55 |
| ▸ | PI4KA | P42356 | 1/20 | 0.55 |
| ▸ | PRKDC | P78527 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6550310 | 1.00 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48618 | 0.88 | PIK3CG (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48617 | 0.88 | PIK3CG (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48616 | 0.88 | PIK3CG (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48896 | 0.88 | PIK3CD (0.62) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL5785803 | 0.86 | PIK3CG (0.70) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48625 | 0.86 | PIK3CD (0.67) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48726 | 0.86 | PIK3CD (0.60) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL49493 | 0.86 | PIK3CG (0.62) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL49041 | 0.85 | PIK3CD (0.66) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480962-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | Novartis AG (CH) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003072557-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2003-09-04 | — | — | WO | disclosed |