Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.59 |
| ▸ | PPARA | Q07869 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10976323 | 0.92 | PPARG (0.52) | PPARGPPARANPSR1PTGDR2KDM4E | |
| SCHEMBL11411964 | 0.89 | SRD5A2 (0.57) | PPARGPPARANPSR1PTGDR2GAA | |
| SCHEMBL4780627 | 0.86 | EPHX1 (0.51) | PPARGPPARANPSR1KDM4EGAA | |
| SCHEMBL6549025 | 0.86 | PPARG (0.53) | PPARGPPARANPSR1KDM4EGAA | |
| SCHEMBL232456 | 0.85 | CYP1A2 (0.51) | PPARGPPARAGAACYP1A2CYP2C9 | |
| SCHEMBL10931369 | 0.85 | TDP1 (0.50) | PPARGPPARAPTGDR2GAACYP1A2 | |
| SCHEMBL11223862 | 0.84 | NPSR1 (0.52) | PPARGPPARANPSR1KDM4EGAA | |
| SCHEMBL5539199 | 0.82 | PPARG (0.61) | PPARGPPARANPSR1KDM4EGAA | |
| SCHEMBL5207539 | 0.82 | PPARG (0.51) | PPARGPPARANPSR1KDM4EGAA | |
| SCHEMBL25212758 | 0.81 | CYP1A2 (0.59) | PPARGPPARANPSR1PTGDR2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8669255-B2 | Substituted octahydropyrrolo[1,2-a]pyrazines as calcium channel blockers | ABBVIE INC. (US) | 2014-03-11 | — | — | US | disclosed |
| US-20130085142-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | ABBVIE INC. (US) | 2013-04-04 | — | — | US | disclosed |
| WO-2013049164-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | ABBVIE INC. (US) | 2013-04-04 | — | — | WO | disclosed |
| EP-1180515-B9 | BENZOXAZOLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND HERBICIDES | UBE INDUSTRIES (JP) | 2004-12-01 | — | — | EP | disclosed |
| EP-1180515-B1 | BENZOXAZOLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND HERBICIDES | UBE INDUSTRIES (JP) | 2004-04-14 | — | — | EP | disclosed |
| US-6706664-B1 | Benzoxazole compounds, process for the preparation thereof and herbicides | UBE INDUSTRIES, LTD. (JP) | 2004-03-16 | — | — | US | disclosed |
| EP-1180515-A1 | BENZOXAZOLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND HERBICIDES | Ube Industries, Ltd. (JP) | 2002-02-20 | — | — | EP | disclosed |
| US-4304907-A | Bicyclo lactone intermediates for prostaglandin analogs | THE UPJOHN COMPANY (US) | 1981-12-08 | — | — | US | disclosed |
| US-4303796-A | 16-Phenoxy prostaglandin F2α analogs | THE UPJOHN COMPANY (US) | 1981-12-01 | — | — | US | disclosed |
| US-4154950-A | PROSTAGLANDIN, WOUND HEALING AGENTS, OXYTOCICS, ANTIULCER AGENTS, ANTICOAGULANT, DECONGESTANT | THE UPJOHN COMPANY (US) | 1979-05-15 | — | — | US | disclosed |
| US-4116989-A | 16-Phenoxy prostaglandin F1α analogs | THE UPJOHN COMPANY (US) | 1978-09-26 | — | — | US | disclosed |
| US-4087616-A | 16-Phenoxy prostaglandin A2 analogs | THE UPJOHN COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130085142-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | CACNA1C, CACNA1E, CACNA1D | PPARG 3460/4885PPARA 3235/4885NPSR1 361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.