Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5787843 | 0.85 | PIK3CG (0.39) | PIK3CDPIK3CAPIK3CGPIK3CBEDNRA | |
| SCHEMBL5783825 | 0.82 | PIK3CG (0.64) | PIK3CDPIK3CAPIK3CGPIK3CB | |
| Sulfuric Acid SCHEMBL17203104 | 0.81 | PIK3CG (0.62) | PIK3CDPIK3CAPIK3CGPIK3CB | |
| Sulfuric Acid SCHEMBL17203140 | 0.80 | PIK3CG (0.61) | PIK3CDPIK3CAPIK3CGPIK3CB | |
| Sulfuric Acid SCHEMBL17203055 | 0.80 | PIK3CG (0.61) | PIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL6550300 | 0.78 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CGPIK3CBABL1 | |
| SCHEMBL4033143 | 0.77 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL2074226 | 0.77 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CGPIK3CB | |
| Water SCHEMBL17203105 | 0.77 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL17203053 | 0.77 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480962-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | Novartis AG (CH) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003072557-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2003-09-04 | — | — | WO | disclosed |