Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31059180 | 0.91 | KDM4E (0.68) | KDM4ETSHRTDP1NPSR1POLB | |
| SCHEMBL12819456 | 0.91 | KDM4E (0.68) | KDM4ETSHRTDP1NPSR1POLB | |
| SCHEMBL31059181 | 0.91 | KDM4E (0.68) | KDM4ETSHRTDP1NPSR1POLB | |
| SCHEMBL14067402 | 0.88 | KDM4E (0.60) | KDM4ETSHRTDP1NPSR1POLB | |
| SCHEMBL6979275 | 0.84 | HSD17B10 (0.57) | KDM4ETSHRTDP1NPSR1POLB | |
| SCHEMBL172602 | 0.84 | KDM4E (0.65) | KDM4ETSHRTDP1NPSR1POLB | |
| SCHEMBL654006 | 0.83 | HRH1 (0.61) | KDM4ETSHRTDP1NPSR1POLB | |
| SCHEMBL13955394 | 0.83 | KDM4E (0.59) | KDM4ETSHRTDP1NPSR1POLB | |
| SCHEMBL6785130 | 0.83 | KDM4E (0.59) | KDM4ETSHRTDP1NPSR1POLB | |
| SCHEMBL6033690 | 0.82 | KDM4E (0.67) | KDM4ETSHRTDP1NPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8242148-B2 | Treatment methods employing histamine H3 receptor antagonists, including betahistine | OTOLANUM AG, C/O AURIS MEDICAL HOLDING AG (CH) | 2012-08-14 | — | — | US | disclosed |
| US-20120115914-A1 | Treatment Methods Employing Histamine H3 Receptor Antagonists, Including Betahistine | OTOLANUM AG, C/O AURIS MEDICAL HOLDING AG (CH) | 2012-05-10 | — | — | US | disclosed |
| US-8119668-B2 | Treatment methods employing histamine H3 receptor antagonists, including betahistine | OTOLANUM AG, C/O AURIS MEDICAL HOLDING AG (CH) | 2012-02-21 | — | — | US | disclosed |
| US-20090298892-A1 | Treatment Methods Employing Histamine H3 Receptor Antagonists, Including Betahistine | OTOLANUM AG, C/O AURIS MEDICAL HOLDING AG (CH) | 2009-12-03 | — | — | US | disclosed |
| WO-2007076140-A2 | TREATMENT METHODS EMPLOYING HISTAMINE H3 RECEPTOR ANTAGONISTS, INCLUDING BETAHISTINE | UNIVERSITY OF CINCINNATI (US) | 2007-07-05 | — | — | WO | disclosed |