Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.73 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.73 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 17/20 | 0.73 |
| ▸ | TNF | P01375 | 2/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2461834 | 0.88 | TNF (0.59) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL7433881 | 0.87 | TNF (0.68) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6555476 | 0.86 | PDE4B (0.80) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL23000632 | 0.86 | TNF (0.75) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL29651471 | 0.86 | PDE4B (0.78) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6098123 | 0.86 | TNF (0.75) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL23000615 | 0.86 | TNF (0.75) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL1193538 | 0.86 | PDE4B (0.78) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL15198844 | 0.86 | PDE4B (0.78) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL7741608 | 0.85 | TNF (0.88) | PDE4APDE4BPDE4CPDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0851857-B1 | INHIBITORS OF TUMOR NECROSIS FACTOR ALPHA | CELGENE CORP (US) | 2004-02-18 | — | — | EP | disclosed |
| EP-1367051-A2 | Inhibitors of tumor necrosis factor alpha | CELGENE CORPORATION (US) | 2003-12-03 | — | — | EP | disclosed |
| EP-0957091-B1 | Inhibitors of tumor necrosis factor alpha | CELGENE CORP (US) | 2003-06-04 | — | — | EP | disclosed |
| US-6200987-B1 | ADMINISTERING AS TUMOR NECROSIS FACTOR INHIBITORS; CACHEXIA, ENDOTOXIN SHOCK; RETROVIRUS VIRICIDES | CELGENE CORPORATION | 2001-03-13 | — | — | US | disclosed |
| US-6075041-A | TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 2000-06-13 | — | — | US | disclosed |
| EP-0957091-A1 | Inhibitors of tumor necrosis factor alpha | CELGENE CORPORATION (US) | 1999-11-17 | — | — | EP | disclosed |
| US-5877200-A | Cyclic amides | CELGENE CORPORATION (US) | 1999-03-02 | — | — | US | disclosed |
| US-5698579-A | INHIBITOR OF TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-12-16 | — | — | US | disclosed |