SCHEMBL6553791

SCHEMBL6553791

CCOP(=O)(OCC)C(I)(CC)C(=O)O

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.36
PPARD Q03181 2/20 0.33
TP53 P04637 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32
CYP3A4 P08684 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2079486 0.75 TSHR (0.39) TSHRPPARDTP53TDP1SMN1; SMN2
SCHEMBL8820544 0.75 TSHR (0.39) TSHRPPARDTP53TDP1SMN1; SMN2
SCHEMBL7490235 0.73 TSHR (0.37) TSHRPPARDTP53TDP1SMN1; SMN2
SCHEMBL14105288 0.72 TSHR (0.40) TSHRPPARDTP53TDP1SMN1; SMN2
SCHEMBL905270 0.72 TSHR (0.36) TSHRPPARDTP53TDP1SMN1; SMN2
SCHEMBL3170237 0.72 TP53 (0.38) TSHRPPARDTP53TDP1SMN1; SMN2
SCHEMBL17960647 0.72 TSHR (0.43) TSHRPPARDTP53TDP1
SCHEMBL11430886 0.71 TP53 (0.41) TSHRPPARDTP53TDP1SMN1; SMN2
SCHEMBL10590583 0.71 TSHR (0.41) TSHRPPARDTP53TDP1CA12
SCHEMBL1749816 0.71 TP53 (0.37) TSHRPPARDTP53TDP1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1149067-B1 7-ARYL-6(Z)HEPTATRIENOIC ACID RETINAMIDES AS APOPTOSIS INDUCING COMPOUNDS AND THEIR USE AS ANTI-CANCER AGENTS HOFFMANN LA ROCHE (CH) 2004-02-25 EP disclosed
EP-1149067-A1 7-ARYL-6(Z)HEPTATRIENOIC ACID RETINAMIDES AS APOPTOSIS INDUCING COMPOUNDS AND THEIR USE AS ANTI-CANCER AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2001-10-31 EP disclosed
US-6310247-B1 HAS APOPTOTIC ACTIVITY USEFUL FOR PROPHYLAXIS AND THERAPY OF CANCER HOFFMANN-LA ROCHE INC. 2001-10-30 US disclosed
WO-2000035856-A1 7-ARYL-6(Z)HEPTATRIENOIC ACID RETINAMIDES AS APOPTOSIS INDUCING COMPOUNDS AND THEIR USE AS ANTI-CANCER AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2000-06-22 WO disclosed