Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 4/20 | 0.37 |
| ▸ | CDK7 | P50613 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | MARK3 | P27448 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6554280 | 1.00 | GPR17 (0.37) | GPR17CDK7MEN1LMNAPOLB | |
| SCHEMBL6554266 | 0.83 | CSNK2A1 (0.45) | FLT3CSNK2A1NTRK1DYRK3MAP4K4 | |
| SCHEMBL6554271 | 0.83 | CSNK2A1 (0.45) | FLT3CSNK2A1NTRK1DYRK3MAP4K4 | |
| SCHEMBL6554464 | 0.80 | HTT (0.38) | FLT3CSNK2A1NTRK1DYRK3MAP4K4 | |
| SCHEMBL4009506 | 0.79 | CDK7 (0.48) | GPR17CDK7FLT3CSNK2A1NTRK1 | |
| SCHEMBL4003421 | 0.79 | CDK7 (0.48) | GPR17CDK7FLT3CSNK2A1NTRK1 | |
| SCHEMBL4006597 | 0.79 | CSNK2A1 (0.52) | GPR17MEN1LMNAPOLBMAPT | |
| SCHEMBL4010178 | 0.79 | FLT3 (0.51) | GPR17MEN1LMNAPOLBMAPT | |
| SCHEMBL4015191 | 0.77 | NTRK1 (0.48) | CSNK2A1NTRK1PRKAA1DYRK1ANTRK3 | |
| SCHEMBL4014969 | 0.76 | FLT3 (0.51) | GPR17MEN1LMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487803-A1 | INDAZOLES SUBSTITUTED WITH AN ANTI-CANCEROUS ACTIVITY | Aventis Pharma S.A. (FR) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078402-A1 | INDAZOLES SUBSTITUTED WITH AN ANTI-CANCEROUS ACTIVITY | AVENTIS PHARMA S.A. (FR) | 2003-09-25 | — | — | WO | disclosed |