Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 5/20 | 0.44 |
| ▸ | ITK | Q08881 | 2/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | SGK1 | O00141 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1460965 | 0.90 | CSNK2A1 (0.45) | HAO1CSNK2A1NTRK1AURKAITK | |
| SCHEMBL1460523 | 0.89 | CSNK2A1 (0.58) | CSNK2A1NTRK1AURKAPRKAA1ROCK1 | |
| SCHEMBL4006567 | 0.89 | CSNK2A1 (0.44) | HAO1CSNK2A1NTRK1AURKAITK | |
| SCHEMBL4014003 | 0.89 | NTRK1 (0.58) | HAO1CSNK2A1NTRK1ITK | |
| SCHEMBL1460752 | 0.86 | ROCK1 (0.58) | CSNK2A1ITKCHEK1PRKD3CDK8 | |
| SCHEMBL4013164 | 0.85 | ITK (0.46) | CSNK2A1NTRK1AURKAITKCHEK1 | |
| SCHEMBL1460787 | 0.84 | MAP2K4 (0.54) | AURKAITKAURKB | |
| SCHEMBL1460552 | 0.84 | MAPK1 (0.54) | CSNK2A1NTRK1AURKAITKPRKD3 | |
| SCHEMBL1459711 | 0.83 | ITK (0.49) | AURKAITKCHEK1PRKD3CDK8 | |
| Water SCHEMBL4009010 | 0.83 | MAP2K4 (0.53) | AURKAITKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487803-A1 | INDAZOLES SUBSTITUTED WITH AN ANTI-CANCEROUS ACTIVITY | Aventis Pharma S.A. (FR) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078402-A1 | INDAZOLES SUBSTITUTED WITH AN ANTI-CANCEROUS ACTIVITY | AVENTIS PHARMA S.A. (FR) | 2003-09-25 | — | — | WO | disclosed |