Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 13/20 | 1.00 |
| ▸ | GRIA2 | P42262 | 8/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4605805 | 1.00 | GRIA4 (1.00) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4607668 | 1.00 | GRIA4 (1.00) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4608168 | 1.00 | GRIA4 (1.00) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4607332 | 0.87 | GRIA4 (1.00) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4608724 | 0.86 | GRIA4 (1.00) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4607921 | 0.86 | GRIA4 (0.77) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4606591 | 0.86 | GRIA4 (1.00) | GRIA4GRIA2KCNH2 | |
| SCHEMBL14141323 | 0.86 | GRIA4 (0.77) | GRIA4GRIA2KCNH2 | |
| SCHEMBL4607609 | 0.86 | GRIA4 (1.00) | GRIA4GRIA2KCNH2 | |
| SCHEMBL14141331 | 0.86 | GRIA4 (0.77) | GRIA4GRIA2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390072-A2 | USE OF AN AMPA RECEPTOR POTENTIATOR FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF TYPE 2 DIABETES | ELI LILLY AND COMPANY (US) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002089848-A2 | USE OF AN AMPA RECEPTOR POTENTIATOR FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF TYPE 2 DIABETES | ELI LILLY AND COMPANY (US) | 2002-11-14 | — | — | WO | disclosed |