Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLL | Q9UGP5 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
| ▸ | HTR2B | P41595 | 4/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6556247 | 1.00 | POLL (0.47) | POLLMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL6556367 | 1.00 | POLL (0.47) | POLLMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL6556368 | 1.00 | POLL (0.47) | POLLMAPTKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL6557747 | 0.99 | POLL (0.46) | POLLMAPTKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL6556544 | 0.99 | POLL (0.46) | POLLMAPTKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL6557739 | 0.99 | POLL (0.46) | POLLMAPTKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL6557744 | 0.99 | POLL (0.46) | POLLMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL6556519 | 0.83 | MAPT (0.46) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6556524 | 0.83 | MAPT (0.46) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6556342 | 0.82 | CDK4 (0.46) | MAPTKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958285-B1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | HOFFMANN LA ROCHE (CH) | 2004-01-07 | — | — | EP | claimed |
| EP-0958285-B1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | HOFFMANN LA ROCHE (CH) | 2004-01-07 | — | — | EP | disclosed |
| US-6310208-B1 | Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | disclosed |