Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 3/20 | 0.41 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557730 | 0.86 | NPC1 (0.49) | NPC1RAB9APOLBMAOBCASP3 | |
| SCHEMBL6556281 | 0.80 | NPC1 (0.46) | NPC1RAB9APOLBMAOBCASP3 | |
| SCHEMBL7297125 | 0.78 | NPC1 (0.44) | NPC1RAB9APOLBMAOBCASP3 | |
| SCHEMBL7297137 | 0.78 | NPC1 (0.48) | NPC1RAB9APOLBMAOBCASP3 | |
| SCHEMBL6556109 | 0.78 | ELANE (0.51) | NPC1RAB9AELANESMN1; SMN2 | |
| SCHEMBL27467966 | 0.77 | NPC1 (0.50) | NPC1RAB9APOLBMAOBCASP3 | |
| SCHEMBL6085892 | 0.77 | ELANE (0.60) | NPC1RAB9AELANE | |
| SCHEMBL6557626 | 0.76 | ELANE (0.54) | NPC1RAB9APOLBELANE | |
| SCHEMBL6805631 | 0.76 | POLB (0.48) | NPC1RAB9APOLBMAOBCASP3 | |
| SCHEMBL8401233 | 0.75 | POLB (0.53) | NPC1RAB9APOLBMAOBCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1188401-C | Heterocyclic amide compound and its pharmaceutical use | MITSUBISHI PHARMACEUTICAL CO L (JP) | 2005-02-09 | — | — | CN | disclosed |
| EP-0826671-B1 | HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME | MITSUBISHI PHARMA CORP (JP) | 2004-12-29 | — | — | EP | disclosed |
| CN-1131210-C | Heterocyclic amide compound and medical use thereof | MITSUBISHI SEIYAKU CO LTD (JP) | 2003-12-17 | — | — | CN | disclosed |
| CN-1304931-A | Heterocyclic amide compound and medical use thereof | EFUKU CO LTD (JP) | 2001-07-25 | — | — | CN | disclosed |
| US-5948785-A | USEFUL AS CHYMASE INHIBITORS AND CAN BE EFFECTIVE FOR THE PROPHYLAXIS AND TREATMENT OF VARIOUS DISEASES CAUSED BY CHYMASE, SUCH AS THOSE CAUSED BY ANGIOTENSIN II. | THE GREEN CROSS CORPORATION (JP) | 1999-09-07 | — | — | US | disclosed |
| CN-1188472-A | Heterocyclic amide compound and medical use thereof | GREEN CROSS CORP (JP) | 1998-07-22 | — | — | CN | disclosed |
| EP-0826671-A1 | HETEROCYCLIC AMIDE COMPOUNDS AND MEDICINAL USE OF THE SAME | THE GREEN CROSS CORPORATION (JP) | 1998-03-04 | — | — | EP | disclosed |