Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.39 |
| ▸ | AKT1 | P31749 | 3/20 | 0.35 |
| ▸ | AKT2 | P31751 | 3/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL657703 | 0.92 | HDAC1 (0.39) | HDAC1AKT1AKT2MAP3K14PIK3CD | |
| SCHEMBL658275 | 0.88 | AKT1 (0.36) | HDAC1AKT1AKT2CDK4CCNE1 | |
| SCHEMBL658761 | 0.88 | AKT1 (0.47) | HDAC1AKT1AKT2MAP3K14 | |
| SCHEMBL655483 | 0.87 | HDAC1 (0.54) | HDAC1 | |
| SCHEMBL655847 | 0.86 | HDAC1 (0.49) | HDAC1AKT1AKT2MAP3K14PIK3CD | |
| SCHEMBL3351646 | 0.85 | AKT1 (0.35) | HDAC1AKT1AKT2PIM1PIM2 | |
| SCHEMBL3358836 | 0.85 | MAP3K14 (0.50) | HDAC1AKT1AKT2MAP3K14PIK3CD | |
| SCHEMBL658247 | 0.83 | HDAC1 (0.39) | HDAC1AKT1AKT2MAP3K14PIK3CD | |
| SCHEMBL3352993 | 0.83 | AKT1 (0.36) | HDAC1AKT1AKT2PIM1PIM2 | |
| SCHEMBL700984 | 0.82 | CDK2 (0.47) | HDAC1CDK4CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198299-B2 | Cycloalkylidene and heterocycloalkylidene inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-06-12 | — | — | US | claimed |
| US-20120045412-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2012-02-23 | — | — | US | claimed |
| US-20100022543-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2010-01-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120045412-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE INHIBITOR COMPOUNDS | HDAC1, HDAC11, HDAC2 | HDAC1 1/4885AKT1 1338/4885AKT2 981/4885 |
| US-20100022543-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE INHIBITOR COMPOUNDS | HDAC1, HDAC11, HDAC2 | HDAC1 1/4885AKT1 1338/4885AKT2 981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.