Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | STAT6 | P42226 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11319778 | 0.83 | PDE10A (0.49) | PDE10AALDH1A1EGFRSOS1SMN1; SMN2 | |
| SCHEMBL11307305 | 0.82 | PDE10A (0.59) | PDE10AALDH1A1LMNAKMT2APDE4A | |
| SCHEMBL11310184 | 0.80 | PDE10A (0.49) | PDE10ASOS1LMNAKMT2APDE4A | |
| SCHEMBL3056496 | 0.78 | PDE10A (0.47) | PDE10AALDH1A1SOS1LMNAKMT2A | |
| SCHEMBL3059540 | 0.77 | PDE10A (0.57) | PDE10ALMNAKMT2APDE4APDE4B | |
| SCHEMBL3059781 | 0.77 | PDE10A (0.52) | PDE10AALDH1A1LMNAKMT2AKDM4E | |
| SCHEMBL11177928 | 0.77 | PDE10A (0.47) | PDE10ALMNAKMT2APDE4APDE4B | |
| SCHEMBL3062473 | 0.77 | PDE10A (0.49) | PDE10ASMN1; SMN2LMNAKMT2AACHE | |
| SCHEMBL11170460 | 0.77 | PDE10A (0.49) | PDE10ALMNAKMT2APDE4APDE4B | |
| SCHEMBL3051634 | 0.77 | PDE10A (0.54) | PDE10ALMNAKMT2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1176960-B1 | SYNERGISTIC COMBINATION COMPRISING ROFLUMILAST AND A PDE-3 INHIBITOR | ALTANA PHARMA AG (DE) | 2004-09-29 | — | — | EP | claimed |