Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 5/20 | 1.00 |
| ▸ | EGFR | P00533 | 5/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | GALR3 | O60755 | 2/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276596 | 0.86 | PDE3B (0.75) | PDE3BPDE3AGPR119BRD4 | |
| SCHEMBL7266756 | 0.84 | PDE3B (0.71) | PDE3BPDE3AGPR119GALR3 | |
| SCHEMBL7268541 | 0.80 | PDE3B (0.67) | PDE3BPDE3AEGFRLMNATSHR | |
| SCHEMBL7276740 | 0.79 | PDE3B (0.64) | PDE3BPDE3AGPR119GALR3 | |
| SCHEMBL7307881 | 0.78 | PDE3B (0.63) | PDE3BPDE3AGPR119GALR3BRD4 | |
| SCHEMBL16491995 | 0.78 | PDE3B (0.64) | PDE3BPDE3AGPR119ALDH1A1GALR3 | |
| SCHEMBL7276606 | 0.77 | PDE3B (0.64) | PDE3BPDE3AGPR119LMNAMAPK1 | |
| SCHEMBL7275405 | 0.77 | PDE3B (0.62) | PDE3BPDE3AGPR119GALR3 | |
| SCHEMBL7275287 | 0.77 | PDE3B (0.62) | PDE3BPDE3AGPR119GALR3 | |
| SCHEMBL2592062 | 0.77 | PDE3B (0.62) | PDE3BPDE3AGPR119ALDH1A1GALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1176960-B1 | SYNERGISTIC COMBINATION COMPRISING ROFLUMILAST AND A PDE-3 INHIBITOR | ALTANA PHARMA AG (DE) | 2004-09-29 | — | — | EP | claimed |
| EP-1176960-B1 | SYNERGISTIC COMBINATION COMPRISING ROFLUMILAST AND A PDE-3 INHIBITOR | ALTANA PHARMA AG (DE) | 2004-09-29 | — | — | EP | disclosed |