⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18886839 | 0.75 | MAP4K4 (0.35) | — | |
| SCHEMBL11707680 | 0.72 | — | — | |
| SCHEMBL28309527 | 0.72 | — | — | |
| SCHEMBL27739596 | 0.72 | — | — | |
| SCHEMBL5081060 | 0.72 | — | — | |
| SCHEMBL19491720 | 0.72 | — | — | |
| SCHEMBL27977646 | 0.72 | — | — | |
| SCHEMBL3934072 | 0.72 | — | — | |
| SCHEMBL27592302 | 0.69 | PARP1 (0.36) | — | |
| SCHEMBL7072277 | 0.69 | GLA (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120158224-A | Protective coating with stealth function and preparation method thereof | 蓝箭航天材料(开化)有限公司 | 2025-06-17 | — | — | CN | claimed |
| CN-120158224-A | Protective coating with stealth function and preparation method thereof | 蓝箭航天材料(开化)有限公司 | 2025-06-17 | — | — | CN | disclosed |
| WO-2024245115-A1 | PREPARATION METHOD FOR PYRROLOTRIAZINE COMPOUND | 临海市华南化工有限公司 | 2024-12-05 | — | — | WO | disclosed |
| CN-113480548-B | Preparation method of 4-aminopyrrolo [2,1-f ] [1,2,4] triazine | 山东三牧新材料科技有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-113480548-A | Preparation method of 4-aminopyrrolo [2,1-f ] [1,2,4] triazine | 山东三牧新材料科技有限公司 | 2021-10-08 | — | — | CN | disclosed |
| WO-2019149114-A1 | PREPARATION AND USE OF COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT OR COMPOSITION THEREOF | 深圳铂立健医药有限公司 | 2019-08-08 | — | — | WO | disclosed |
| CN-104003990-B | Heterocyclic amine Hedgehog signal pathway inhibitors | 江苏先声药业有限公司 | 2017-09-15 | — | — | CN | disclosed |
| EP-2168968-B1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS LLC (US) | 2017-08-23 | — | — | EP | disclosed |
| US-9718828-B2 | BTK Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-01 | — | — | US | disclosed |
| US-20170008899-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-01-12 | — | — | US | disclosed |
| US-7223766-B2 | Bi-cyclic pyrimidine inhibitors of TGFβ | SCIOS, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-7223766-B2 | Bi-cyclic pyrimidine inhibitors of TGFβ | SCIOS, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| WO-2007056170-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2007-05-18 | — | — | WO | disclosed |
| US-20070112005-A1 | mammalian Target Of Rapamycin (mTOR) kinase; for treatment of lymphoma or ovarian cancer | OSI PHARMACEUTICALS, INC. | 2007-05-17 | — | — | US | disclosed |
| US-20070032512-A1 | 6,6-Bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS, INC., | 2007-02-08 | — | — | US | disclosed |
| US-20060235031-A1 | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors | ACERTA PHARMA B.V. (NL) | 2006-10-19 | — | — | US | disclosed |
| WO-2006035061-A1 | HCV INHIBITING BI-CYCLIC PYRIMIDINES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2006-04-06 | — | — | WO | disclosed |
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | disclosed |
| US-20050004143-A1 | Bi-cyclic pyrimidine inhibitors of TGFbeta | SCIOS, INC. | 2005-01-06 | — | — | US | disclosed |
| EP-0061056-A1 | 5,6-Dimethylpyrrolo (2,3-b) pyridines, process for their preparation and their use as medicaments | Troponwerke GmbH & Co. KG (DE) | 1982-09-29 | — | — | EP | disclosed |