Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.74 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | FNTA | P49354 | 2/20 | 0.56 |
| ▸ | FNTB | P49356 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.56 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.56 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.56 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.56 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.56 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.56 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29289383 | 1.00 | GPBAR1 (0.74) | GPBAR1LMNANPC1L1USP2TDP1 | |
| SCHEMBL11415673 | 1.00 | GPBAR1 (0.74) | GPBAR1LMNANPC1L1USP2TDP1 | |
| Ethylene SCHEMBL11411567 | 0.93 | GPBAR1 (0.66) | GPBAR1LMNANPC1L1USP2TDP1 | |
| SCHEMBL23695768 | 0.91 | GPBAR1 (0.61) | GPBAR1LMNANPC1L1USP2TDP1 | |
| SCHEMBL5919568 | 0.89 | GPBAR1 (0.60) | GPBAR1LMNANPC1L1USP2TDP1 | |
| SCHEMBL5919527 | 0.89 | GPBAR1 (0.60) | GPBAR1LMNANPC1L1USP2TDP1 | |
| SCHEMBL11418134 | 0.89 | GPBAR1 (0.60) | GPBAR1LMNANPC1L1USP2TDP1 | |
| SCHEMBL23845852 | 0.89 | GPBAR1 (0.60) | GPBAR1LMNANPC1L1USP2EPHA2 | |
| SCHEMBL25711971 | 0.87 | GPBAR1 (0.58) | GPBAR1LMNANPC1L1USP2EPHA2 | |
| SCHEMBL2482340 | 0.86 | USP2 (0.73) | GPBAR1LMNANPC1L1USP2FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040171811-A1 | Nonhuman pregnane x receptor sequences for use in comparative pharmacology | SMITHKLINE BEECHAM CORPORATION | 2004-09-02 | — | — | US | disclosed |
| EP-1392725-A1 | NONHUMAN PREGNANE X RECEPTOR SEQUENCES FOR USE IN COMPARATIVE PHARMACOLOGY | SmithKline Beecham Corporation (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002094865-A1 | NONHUMAN PREGNANE X RECEPTOR SEQUENCES FOR USE IN COMPARATIVE PHARMACOLOGY | SMITHKLINE BEECHAM CORPORATION (US) | 2002-11-28 | — | — | WO | disclosed |