Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 13/20 | 0.50 |
| ▸ | PPARD | Q03181 | 13/20 | 0.50 |
| ▸ | PPARA | Q07869 | 12/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7044493 | 0.85 | PPARG (0.56) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6559350 | 0.82 | GRM2 (0.40) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL7044491 | 0.81 | PPARG (0.51) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6560646 | 0.78 | PPARG (0.61) | PPARGPPARDPPARALTB4RLTB4R2 | |
| SCHEMBL6559345 | 0.78 | GRM2 (0.40) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6559377 | 0.77 | PPARG (0.65) | PPARGPPARDPPARALTB4R | |
| SCHEMBL7038241 | 0.74 | PPARD (0.61) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6560112 | 0.74 | PPARD (0.71) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6560086 | 0.73 | PPARD (0.59) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6560654 | 0.73 | PPARD (0.66) | PPARGPPARDPPARANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904079-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2004-03-24 | — | — | EP | claimed |
| EP-0904079-A4 | — | — | 1999-05-06 | — | — | EP | claimed |
| EP-0904079-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-03-31 | — | — | EP | claimed |
| WO-1997027857-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | claimed |
| EP-0904079-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2004-03-24 | — | — | EP | disclosed |
| EP-0904079-A4 | — | — | 1999-05-06 | — | — | EP | disclosed |
| EP-0904079-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5859051-A | ACETYLPHENOL DERIVATIVES | MERCK & CO., INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1997027857-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |