Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | F2 | P00734 | 1/20 | 0.62 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.62 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5217325 | 1.00 | KDM4E (0.68) | KDM4EHRH3KMT2AMEN1NPSR1 | |
| SCHEMBL4197501 | 0.98 | KDM4E (0.69) | KDM4EHRH3KMT2AMEN1NPSR1 | |
| SCHEMBL5800630 | 0.95 | KDM4E (0.69) | KDM4EHRH3KMT2AMEN1NPSR1 | |
| SCHEMBL25885761 | 0.89 | KMT2A (0.57) | KDM4EHRH3KMT2AMEN1NPSR1 | |
| SCHEMBL17863558 | 0.88 | KDM4E (0.54) | KDM4EHRH3KMT2AMEN1NPSR1 | |
| SCHEMBL27390997 | 0.85 | HRH3 (0.78) | KDM4EHRH3KMT2AMEN1NPSR1 | |
| SCHEMBL23252438 | 0.85 | KMT2A (0.55) | KDM4EHRH3KMT2AMEN1NPSR1 | |
| SCHEMBL27514596 | 0.85 | KDM4E (0.66) | KDM4EHRH3KMT2AMEN1NPSR1 | |
| SCHEMBL17864835 | 0.84 | KDM4E (0.51) | KDM4EHRH3KMT2AMEN1NPSR1 | |
| SCHEMBL14529027 | 0.84 | HRH3 (0.80) | KDM4EHRH3KMT2AMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436255-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2004-07-14 | — | — | EP | claimed |
| WO-2003024924-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2003-03-27 | — | — | WO | claimed |