Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 14/20 | 0.48 |
| ▸ | PPARG | P37231 | 13/20 | 0.48 |
| ▸ | PPARD | Q03181 | 9/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 4/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560063 | 0.93 | PPARA (0.56) | PPARAPPARGPPARDCYSLTR2CYSLTR1 | |
| SCHEMBL7044211 | 0.86 | PPARA (0.49) | PPARAPPARGPPARD | |
| SCHEMBL7042004 | 0.79 | PPARA (0.59) | PPARAPPARGPPARD | |
| SCHEMBL6560061 | 0.78 | PPARG (0.63) | PPARAPPARGPPARDLTB4RNR1H2 | |
| SCHEMBL6559245 | 0.77 | PPARA (0.75) | PPARAPPARGPPARDNR1H2NR1H3 | |
| SCHEMBL6560554 | 0.77 | PPARA (0.59) | PPARAPPARGPPARD | |
| SCHEMBL6559385 | 0.75 | PPARA (0.53) | PPARAPPARGPPARD | |
| SCHEMBL2066214 | 0.74 | PPARG (0.77) | PPARAPPARGPPARDNR1H2NR1H3 | |
| SCHEMBL6561582 | 0.74 | PPARA (0.66) | PPARAPPARGPPARDNR1H2NR1H3 | |
| SCHEMBL6559335 | 0.74 | PPARA (0.64) | PPARAPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904079-A4 | — | — | 1999-05-06 | — | — | EP | claimed |
| EP-0904079-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-03-31 | — | — | EP | claimed |
| WO-1997027857-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | claimed |
| EP-0904079-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2004-03-24 | — | — | EP | disclosed |
| EP-0904079-A4 | — | — | 1999-05-06 | — | — | EP | disclosed |
| EP-0904079-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5859051-A | ACETYLPHENOL DERIVATIVES | MERCK & CO., INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1997027857-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |