Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.60 |
| ▸ | ACE | P12821 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480343 | 1.00 | DPP4 (0.60) | DPP4ACEMAPTCYP3A4TSHR | |
| SCHEMBL4480365 | 1.00 | DPP4 (0.60) | DPP4ACEMAPTCYP3A4TSHR | |
| SCHEMBL4495195 | 1.00 | DPP4 (0.60) | DPP4ACEMAPTCYP3A4TSHR | |
| SCHEMBL6560264 | 1.00 | DPP4 (0.60) | DPP4ACEMAPTCYP3A4TSHR | |
| SCHEMBL6560281 | 1.00 | DPP4 (0.60) | DPP4ACEMAPTCYP3A4TSHR | |
| SCHEMBL4490580 | 1.00 | DPP4 (0.60) | DPP4ACEMAPTCYP3A4TSHR | |
| SCHEMBL10793019 | 0.88 | ACE (0.51) | DPP4ACEMAPTCYP3A4TSHR | |
| SCHEMBL7340816 | 0.88 | ACE (0.51) | DPP4ACEMAPTCYP3A4TSHR | |
| SCHEMBL10793023 | 0.88 | ACE (0.51) | DPP4ACEMAPTCYP3A4TSHR | |
| SCHEMBL10915073 | 0.87 | ACE (0.50) | DPP4ACEMAPTCYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395606-A1 | PYRROLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF FACTOR XA | GLAXO GROUP LIMITED (GB) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002100886-A1 | PYRROLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF FACTOR XA | GLAXO GROUP LIMITED (GB) | 2002-12-19 | — | — | WO | disclosed |