SCHEMBL6560760

SCHEMBL6560760

O=C1c2ccccc2C(=O)c2c1ccc(O)c2Cl

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 9/20 0.67
KMT2A Q03164 9/20 0.67
MAPT P10636 8/20 0.67
MCL1 Q07820 7/20 0.67
MAOA P21397 7/20 0.67
ALDH1A1 P00352 7/20 0.67
MAPK1 P28482 5/20 0.67
HPGD P15428 5/20 0.67
BCL2 P10415 4/20 0.67
ALOX15 P16050 4/20 0.67
HSD17B10 Q99714 4/20 0.67
RECQL P46063 4/20 0.67
SMN1; SMN2 Q16637 3/20 0.67
KDM4E B2RXH2 3/20 0.67
CYP3A4 P08684 3/20 0.67
APEX1 P27695 3/20 0.67
ALOX12 P18054 2/20 0.67
DAPK1 P53355 2/20 0.67
CYP1B1 Q16678 2/20 0.67
TDP1 Q9NUW8 6/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Athraquinones A SCHEMBL29373337 0.80 MAPT (1.00) MEN1KMT2AMAPTMCL1MAOA
Athraquinones A SCHEMBL18614 0.80 MAPT (1.00) MEN1KMT2AMAPTMCL1MAOA
Athraquinones A SCHEMBL21114402 0.80 MAPT (1.00) MEN1KMT2AMAPTMCL1MAOA
SCHEMBL583089 0.80 ADORA2A (0.53) MEN1KMT2AMAPTMCL1MAOA
Athraquinones A SCHEMBL4972786 0.80 MAPT (1.00) MEN1KMT2AMAPTMCL1MAOA
Quinizarin SCHEMBL25194269 0.79 MEN1 (0.95) MEN1KMT2AMAPTMCL1MAOA
Athraquinones A SCHEMBL11805858 0.78 MAPT (0.96) MEN1KMT2AMAPTMCL1MAOA
Athraquinones A SCHEMBL22471867 0.78 MAPT (0.96) MEN1KMT2AMAPTMCL1MAOA
Athraquinones A SCHEMBL3228431 0.78 MAPT (0.96) MEN1KMT2AMAPTMCL1MAOA
Athraquinones A SCHEMBL7839563 0.78 MAPT (0.96) MEN1KMT2AMAPTMCL1MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1074586-B1 Process for the preparation of arylaminohydroxyanthraquinones BAYER CHEMICALS AG (DE) 2004-05-19 EP claimed
US-6420576-B1 AMINATION OF ANTHRAQUINONE WITH AMINE IN SOLVENT BAYER AKTIENGESELLSCHAFT (DE) 2002-07-16 US claimed
US-11401234-B2 Deuterated compounds and uses thereof OncoTherics Ventures Limited (GB) 2022-08-02 US disclosed
CN-109836343-B Process for preparing phenylaminohydroxyanthraquinones 朗盛德国有限责任公司 2022-02-11 CN disclosed
US-20200270200-A1 DEUTERATED COMPOUNDS AND USES THEREOF OncoTherics Ventures Limited (GB) 2020-08-27 US disclosed
US-10385009-B2 Deuterated compounds and uses thereof BIOSTATUS LIMITED (GB) 2019-08-20 US disclosed
US-20190161617-A1 METHOD FOR PREPARING PHENYLAMINOHYDROXYANTHRAQUINONES LANXESS DEUTSCHLAND GMBH (DE) 2019-05-30 US disclosed
EP-2882708-B1 NEW COMPOUNDS AND USES THEREOF BIOSTATUS LTD (GB) 2018-10-03 EP disclosed
US-20150307441-A1 NEW COMPOUNDS AND USES THEREOF BIOSTATUS LIMITED (GB) 2015-10-29 US disclosed
EP-2882708-A1 NEW COMPOUNDS AND USES THEREOF Biostatus Limited (GB) 2015-06-17 EP disclosed
WO-2014023956-A1 NEW COMPOUNDS AND USES THEREOF BIOSTATUS LIMITED (GB) 2014-02-13 WO disclosed
US-6420576-B1 AMINATION OF ANTHRAQUINONE WITH AMINE IN SOLVENT BAYER AKTIENGESELLSCHAFT (DE) 2002-07-16 US disclosed
WO-2001044190-A1 ANTHRACENE DERIVATIVES AS ANTI-CANCER AGENTS BTG INTERNATIONAL LIMITED (GB) 2001-06-21 WO disclosed
JP-2001055519-A PRODUCTION OF ARYLAMINOHYDROXYANTHRAQUINONES BAYER AG 2001-02-27 JP disclosed
CN-1283613-A Method for prepn, of arylamino hydroxy anthraquinone BAYER AG (DE) 2001-02-14 CN disclosed
EP-1074586-A1 Process for the preparation of arylaminohydroxyanthraquinones BAYER AG (DE) 2001-02-07 EP disclosed
EP-0450021-B1 ANTI-CANCER COMPOUNDS BRITISH TECH GROUP (GB) 1994-02-02 EP disclosed
US-5132327-A ANTI-CANCER COMPOUNDS NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1992-07-21 US disclosed
EP-0450021-A1 ANTI-CANCER COMPOUNDS. NAT RES DEV (GB) 1991-10-09 EP disclosed
WO-1991005824-A1 ANTI-CANCER COMPOUNDS NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1991-05-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10385009-B2 Deuterated compounds and uses thereof HIF1AN, HIF1A, EGLN2 MEN1 2943/4885KMT2A 2099/4885MAPT 4842/4885
US-11401234-B2 Deuterated compounds and uses thereof HIF1AN, HIF1A, EGLN2 MEN1 2862/4885KMT2A 2124/4885MAPT 4837/4885
US-20150307441-A1 NEW COMPOUNDS AND USES THEREOF HIF1AN, HIF1A, EGLN2 MEN1 2915/4885KMT2A 2584/4885MAPT 4829/4885
US-20200270200-A1 DEUTERATED COMPOUNDS AND USES THEREOF HIF1AN, HIF1A, EGLN2 MEN1 2862/4885KMT2A 2124/4885MAPT 4837/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.