Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 16/20 | 0.60 |
| ▸ | OPRM1 known ✓ | P35372 | 3/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 17/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | HRH1 | P35367 | 3/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.54 |
| ▸ | HTR2B | P41595 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.54 |
| ▸ | KLF10 | Q13118 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL5869362 | 1.00 | SLC6A2 (0.60) | SLC6A2SLC6A4PMP22CYP2D6CYP1A2 | |
| Oxalic Acid SCHEMBL5869360 | 1.00 | SLC6A2 (0.60) | SLC6A2SLC6A4PMP22CYP2D6CYP1A2 | |
| Oxalic Acid SCHEMBL5869341 | 0.87 | SLC6A4 (0.64) | SLC6A2SLC6A4CYP2D6CYP1A2CYP3A4 | |
| Oxalic Acid SCHEMBL5869712 | 0.85 | SLC6A2 (0.48) | SLC6A2SLC6A4PMP22CYP2D6SLC6A3 | |
| Oxalic Acid SCHEMBL5869404 | 0.85 | SLC6A2 (0.48) | SLC6A2SLC6A4PMP22CYP2D6SLC6A3 | |
| SCHEMBL5869350 | 0.85 | SLC6A4 (0.67) | SLC6A2SLC6A4PMP22CYP2D6CYP1A2 | |
| SCHEMBL5869354 | 0.85 | SLC6A4 (0.67) | SLC6A2SLC6A4PMP22CYP2D6CYP1A2 | |
| SCHEMBL5869283 | 0.83 | SLC6A2 (0.68) | SLC6A2SLC6A4PMP22CYP2D6CYP1A2 | |
| SCHEMBL5869278 | 0.83 | SLC6A2 (0.68) | SLC6A2SLC6A4PMP22CYP2D6CYP1A2 | |
| Oxalic Acid SCHEMBL5869506 | 0.82 | SLC6A2 (0.60) | SLC6A2SLC6A4PMP22CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397129-A1 | HETEROARYLOXY 3-SUBSTITUTED PROPANAMINES S SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002094262-A1 | HETEROARYLOXY 3-SUBSTITUTED PROPANAMINES S SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-11-28 | — | — | WO | disclosed |