Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3659149 | 0.79 | — | — | |
| SCHEMBL12134521 | 0.79 | TSHR (0.39) | TSHRLMNA | |
| SCHEMBL713526 | 0.77 | TSHR (0.38) | TSHRLMNA | |
| SCHEMBL12134522 | 0.77 | TSHR (0.38) | TSHRLMNA | |
| SCHEMBL2838533 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL27486768 | 0.74 | TSHR (0.39) | TSHRLMNA | |
| SCHEMBL8897031 | 0.73 | TSHR (0.35) | TSHRFDPSLMNA | |
| SCHEMBL18759627 | 0.73 | TSHR (0.43) | TSHRFDPSLMNA | |
| SCHEMBL1682640 | 0.73 | — | — | |
| SCHEMBL10286008 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399446-A1 | 2,6,9-SUBSTITUTED PURINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | Cyclacel Limited (GB) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003002565-A1 | 2,6,9-SUBSTITUTED PURINE DERIVATIVES AND THEIR USE N THE TREATMENT OF PROLIFERATIVE DISORDERS | CYCLACEL LIMITED (GB) | 2003-01-09 | — | — | WO | disclosed |