Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646219 | 0.92 | GCK (0.63) | GCKSMN1; SMN2 | |
| SCHEMBL2647382 | 0.91 | GCK (0.53) | GCKSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL2646731 | 0.88 | SMN1; SMN2 (0.57) | GCKSMN1; SMN2LMNA | |
| SCHEMBL2645677 | 0.86 | SMN1; SMN2 (0.53) | GCKSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL2648531 | 0.86 | SMN1; SMN2 (0.55) | GCKSMN1; SMN2KDM4ELMNA | |
| SCHEMBL3389490 | 0.85 | GCK (0.74) | GCK | |
| SCHEMBL27465165 | 0.84 | SMN1; SMN2 (0.53) | GCKSMN1; SMN2KDM4E | |
| SCHEMBL2648477 | 0.84 | SMN1; SMN2 (0.53) | GCKSMN1; SMN2KDM4ELMNA | |
| SCHEMBL2645568 | 0.84 | GCK (0.66) | GCK | |
| SCHEMBL4256251 | 0.84 | GCK (0.61) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169312-B1 | GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2004-10-06 | — | — | EP | disclosed |