SCHEMBL6563557

SCHEMBL6563557

CCC[C@H]1CC[C@H](c2ccc(C(=O)O)c(-c3ccc(C(=O)O[C@H](C)CC(CC)CC)c(F)c3)c2)CC1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.36
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
RARB P10826 3/20 0.34
RARA P10276 2/20 0.34
APP P05067 1/20 0.33
DHODH Q02127 1/20 0.33
MAPK1 P28482 5/20 0.33
RARG P13631 1/20 0.32
DGAT1 O75907 1/20 0.32
POLQ O75417 1/20 0.32
CYP3A4 P08684 1/20 0.32
CAMKK1 Q8N5S9 1/20 0.31
CAMKK2 Q96RR4 1/20 0.31
S1PR1 P21453 1/20 0.31
MMP2 P08253 1/20 0.31
MMP3 P08254 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6563877 0.89 CYP2C9 (0.42) CYP2C9ALDH1A1LMNAMAPTAPP
SCHEMBL6563555 0.80 CYP2C9 (0.43) CYP2C9ALDH1A1LMNAMAPTMAPK1
SCHEMBL5886343 0.80 CYP2C9 (0.41) CYP2C9ALDH1A1LMNAMAPT
SCHEMBL8676866 0.80 CYP2C9 (0.41) CYP2C9ALDH1A1LMNAMAPT
SCHEMBL8025511 0.79 CYP2C9 (0.46) CYP2C9ALDH1A1LMNAMAPTRARB
SCHEMBL8025498 0.79 CYP2C9 (0.46) CYP2C9ALDH1A1LMNAMAPTRARB
SCHEMBL8045331 0.77 CYP2C9 (0.47) CYP2C9ALDH1A1LMNAMAPTDHODH
SCHEMBL7510571 0.77 CYP2C9 (0.47) CYP2C9ALDH1A1LMNAMAPTDHODH
SCHEMBL6563808 0.76 RARB (0.39) ALDH1A1RARBRARARARGPOLQ
SCHEMBL7737178 0.75 CYP2C9 (0.52) CYP2C9ALDH1A1LMNAMAPTRARB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1225212-B1 Optically active compound and liquid crystal composition containing the compound MITSUBISHI GAS CHEMICAL CO (JP) 2004-03-24 EP disclosed
US-6677475-B2 FOR USE IN LIQUID CRYSTAL DISPLAY DEVICE MITSUBISHI GAS CHEMICAL CO., INC. (JP) 2004-01-13 US disclosed
EP-1225212-A1 Optically active compound and liquid crystal composition containing the compound MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2002-07-24 EP disclosed