Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 2/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 5/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | BAX | Q07812 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | ACACA | Q13085 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10785204 | 0.89 | AKR1C3 (0.51) | AKR1C3AKR1C2ESR1ESR2PTGS1 | |
| SCHEMBL5517061 | 0.89 | AKR1C3 (0.51) | AKR1C3AKR1C2ESR1ESR2PTGS1 | |
| SCHEMBL68895 | 0.89 | AKR1C3 (0.51) | AKR1C3AKR1C2ESR1ESR2PTGS1 | |
| SCHEMBL317875 | 0.80 | AKR1C3 (0.75) | AKR1C3AKR1C2MEN1KMT2APTGS1 | |
| SCHEMBL9818100 | 0.80 | AKR1C3 (0.75) | AKR1C3AKR1C2MEN1KMT2APTGS1 | |
| Hydrochloric Acid SCHEMBL10923723 | 0.79 | AKR1C3 (0.73) | AKR1C3AKR1C2MEN1KMT2APTGS1 | |
| SCHEMBL17017218 | 0.77 | AKR1C3 (0.57) | AKR1C3AKR1C2ESR1MEN1KMT2A | |
| SCHEMBL9701361 | 0.77 | CYP2D6 (0.64) | ESR1ESR2MEN1KMT2APTGS1 | |
| SCHEMBL27996252 | 0.77 | MEN1 (0.54) | ESR1ESR2MEN1KMT2ALTA4H | |
| SCHEMBL8455312 | 0.76 | AKR1C3 (0.55) | AKR1C3AKR1C2MEN1KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040234592-A1 | Mixture containing thyroid hormone , ethanolamine and emulsifier | KARO BIO AB (SE) | 2004-11-25 | — | — | US | claimed |
| EP-1404413-A2 | DERMATOLOGICAL FORMULATIONS | KARO BIO AB (SE) | 2004-04-07 | — | — | EP | claimed |
| EP-1398024-A2 | Uses for thyroid hormone compounds | KARO BIO AB (SE) | 2004-03-17 | — | — | EP | claimed |
| EP-0831769-B1 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | KAROBIO AB (SE) | 2003-10-15 | — | — | EP | claimed |
| WO-2002089917-A2 | DERMATOLOGICAL FORMULATIONS | KARO BIO AB (SE) | 2002-11-14 | — | — | WO | claimed |
| CN-101291640-A | Thyroxine compounds for the treatment of burns and fat deposits in humans | THOMAS LAVIN (US) | 2008-10-22 | — | — | CN | disclosed |
| US-20040234592-A1 | Mixture containing thyroid hormone , ethanolamine and emulsifier | KARO BIO AB (SE) | 2004-11-25 | — | — | US | disclosed |
| EP-1404413-A2 | DERMATOLOGICAL FORMULATIONS | KARO BIO AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2002089917-A2 | DERMATOLOGICAL FORMULATIONS | KARO BIO AB (SE) | 2002-11-14 | — | — | WO | disclosed |