Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 2/20 | 0.47 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 4/20 | 0.37 |
| ▸ | CCND1 | P24385 | 4/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | CDK7 | P50613 | 4/20 | 0.37 |
| ▸ | CCNH | P51946 | 4/20 | 0.37 |
| ▸ | CDK1 | P06493 | 3/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3854524 | 1.00 | KCNN4 (0.47) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3852207 | 1.00 | KCNN4 (0.47) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3853261 | 0.86 | KCNN4 (0.50) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3666885 | 0.86 | KCNN4 (0.50) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL4484584 | 0.86 | KCNN4 (0.50) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3307096 | 0.86 | KCNN4 (0.50) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3853041 | 0.83 | KCNN4 (0.47) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3856263 | 0.83 | KCNN4 (0.47) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3862734 | 0.83 | KCNN4 (0.50) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3862881 | 0.83 | KCNN4 (0.50) | KCNN4KIF11GRIN1GRIN2AGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399446-A1 | 2,6,9-SUBSTITUTED PURINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | Cyclacel Limited (GB) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003002565-A1 | 2,6,9-SUBSTITUTED PURINE DERIVATIVES AND THEIR USE N THE TREATMENT OF PROLIFERATIVE DISORDERS | CYCLACEL LIMITED (GB) | 2003-01-09 | — | — | WO | disclosed |