Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 13/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 2/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.43 |
| ▸ | VEGFA | P15692 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL964980 | 0.91 | EGLN1 (0.50) | EGLN1PDE3BPDE3APDE2AFTO | |
| SCHEMBL8625388 | 0.91 | EGLN1 (0.41) | EGLN1KMT2AEGLN3THRATHRB | |
| SCHEMBL1509148 | 0.89 | EGLN1 (0.50) | EGLN1PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL6566125 | 0.89 | EGLN1 (0.52) | EGLN1FTOEGLN3VEGFAFLT1 | |
| SCHEMBL6567272 | 0.88 | EGLN1 (0.47) | EGLN1PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL6565270 | 0.88 | EGLN1 (0.47) | EGLN1PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL6566238 | 0.88 | EGLN1 (0.47) | EGLN1PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL8628234 | 0.84 | EGLN1 (0.45) | EGLN1PDE3BPDE3APDE2AFTO | |
| SCHEMBL8632214 | 0.84 | EGLN1 (0.45) | EGLN1PDE3BPDE3APDE2AFTO | |
| SCHEMBL6565238 | 0.83 | PDE3B (0.47) | KMT2APDE3BPDE3AP2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |