Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 15/20 | 0.74 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.51 |
| ▸ | RXRA | P19793 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | VHL | P40337 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6513456 | 0.89 | NR1H3 (0.76) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6511060 | 0.87 | NR1H3 (0.76) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6511924 | 0.85 | NR1H3 (1.00) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6511804 | 0.85 | NR1H3 (0.77) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6515800 | 0.85 | NR1H3 (0.82) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6513470 | 0.82 | NR1H3 (0.72) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6512034 | 0.82 | NR1H3 (0.71) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6510846 | 0.81 | NR1H3 (0.71) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6511072 | 0.79 | NR1H3 (0.67) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6511025 | 0.74 | NR1H3 (0.61) | NR1H3NR1H2RXRAMEN1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-B1 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LTD (GB) | 2004-11-24 | — | — | EP | claimed |