Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 18/20 | 0.61 |
| ▸ | NR1H2 | P55055 | 9/20 | 0.45 |
| ▸ | RXRA | P19793 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | VHL | P40337 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6512015 | 0.81 | NR1H3 (0.64) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6565757 | 0.80 | NR1H3 (0.63) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6515336 | 0.79 | NR1H3 (0.60) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6512025 | 0.78 | NR1H3 (0.64) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6513480 | 0.78 | NR1H3 (0.60) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6515881 | 0.78 | NR1H3 (0.60) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6512040 | 0.76 | NR1H3 (0.61) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6940623 | 0.75 | NR1H3 (0.66) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6510880 | 0.74 | NR1H3 (0.87) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL6515902 | 0.74 | NR1H3 (0.65) | NR1H3NR1H2RXRAMEN1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-B1 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LTD (GB) | 2004-11-24 | — | — | EP | claimed |