Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.35 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LDHA | P00338 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL226679 | 0.86 | CA4 (0.40) | CA4FAHD1CA1CA2MEN1 | |
| SCHEMBL4410806 | 0.86 | — | — | |
| Bicarbonate SCHEMBL29273171 | 0.83 | CA1 (0.43) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL10755209 | 0.82 | — | — | |
| SCHEMBL29409712 | 0.82 | CA1 (0.39) | CA1CA2 | |
| SCHEMBL10768602 | 0.82 | — | — | |
| Bicarbonate SCHEMBL3824855 | 0.82 | CA4 (0.43) | CA4FAHD1CA1CA2MEN1 | |
| Sulfurous Acid SCHEMBL27338925 | 0.82 | CA1 (0.50) | CA1CA2 | |
| SCHEMBL9807536 | 0.79 | CA1 (0.36) | CA1CA2 | |
| Bicarbonate SCHEMBL28477433 | 0.74 | CA1 (0.42) | CA4FAHD1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115364221-A | Application of up-regulation expression promoter of Apelin/APJ pathway in medicine for treating renal injury caused by paraquat poisoning | 海南医学院第一附属医院 | 2022-11-22 | — | — | CN | disclosed |
| EP-1418950-A1 | SOLID-PHASE NUCLEOPHILIC FLUORINATION | Amersham plc (GB) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003002157-A1 | SOLID-PHASE NUCLEOPHILIC FLUORINATION | AMERSHAM PLC (GB) | 2003-01-09 | — | — | WO | disclosed |