Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.69 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 3/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491584 | 0.94 | HRH3 (0.77) | HRH3HRH4SMN1; SMN2MAOBMAOA | |
| SCHEMBL491606 | 0.83 | HRH3 (0.78) | HRH3HRH4SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1335914 | 0.82 | HRH3 (1.00) | HRH3HRH4MAOBMAOA | |
| SCHEMBL12128667 | 0.81 | HRH3 (1.00) | HRH3HRH4 | |
| SCHEMBL492424 | 0.80 | HRH3 (0.75) | HRH3HRH4SMN1; SMN2MAOBMAOA | |
| SCHEMBL491078 | 0.80 | HRH3 (0.75) | HRH3HRH4SMN1; SMN2MAOBMAOA | |
| SCHEMBL492101 | 0.76 | HRH3 (0.69) | HRH3HRH4SMN1; SMN2MAOBMAOA | |
| SCHEMBL14032560 | 0.74 | HRH3 (0.56) | HRH3NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL22066893 | 0.74 | HRH2 (0.65) | HRH3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL491570 | 0.73 | HRH3 (0.72) | HRH3KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1428820-A1 | Non-imidazole alkylamines as histamine H-3-receptor ligands and their therapeutic applications | BIOPROJET (FR) | 2004-06-16 | — | — | EP | disclosed |