Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2916981 | 0.84 | POLB (0.70) | POLBHTTSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL1886120 | 0.80 | POLB (0.53) | POLBHTTSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6566803 | 0.77 | POLB (0.57) | POLBHTTSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3079819 | 0.77 | POLB (0.60) | POLBHTTSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL13139946 | 0.77 | POLB (0.60) | POLBHTTSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL13178777 | 0.74 | POLB (0.57) | POLBHTTSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL21246678 | 0.73 | POLB (0.44) | POLBHTTSMN1; SMN2MAPTKDM4E | |
| SCHEMBL21246723 | 0.73 | POLB (0.44) | POLBHTTSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL24263392 | 0.73 | POLB (1.00) | POLBHTTSMN1; SMN2LMNAGAA | |
| SCHEMBL21246814 | 0.72 | POLB (0.50) | POLBHTTSMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |