SCHEMBL6567374

SCHEMBL6567374

CC(=O)N1c2ccc([AsH2])cc2C(C)(c2ccccc2)CC1(C)C

nearest known ligand 0.74

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
FSHR P23945 17/20 0.74
MEN1 O00255 1/20 0.72
ADRB2 P07550 1/20 0.72
KMT2A Q03164 1/20 0.72
NPSR1 Q6W5P4 1/20 0.72
TSHR P16473 1/20 0.71
MAPT P10636 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1323743 0.86 MAPT (0.76) FSHRMEN1ADRB2KMT2ANPSR1
SCHEMBL1322362 0.86 FSHR (0.76) FSHRMEN1ADRB2KMT2ANPSR1
SCHEMBL1322278 0.85 TSHR (0.82) FSHRMEN1ADRB2KMT2ANPSR1
SCHEMBL1322184 0.85 FSHR (0.74) FSHRMEN1ADRB2KMT2ANPSR1
SCHEMBL1322285 0.85 FSHR (1.00) FSHRMEN1ADRB2KMT2ANPSR1
SCHEMBL1322918 0.83 FSHR (0.71) FSHRMEN1ADRB2KMT2ANPSR1
SCHEMBL1323374 0.83 FSHR (0.71) FSHRMEN1ADRB2KMT2ANPSR1
SCHEMBL1322911 0.82 FSHR (0.74) FSHRMEN1ADRB2KMT2ANPSR1
SCHEMBL1323552 0.81 TSHR (0.76) FSHRMEN1ADRB2KMT2ANPSR1
SCHEMBL1322912 0.81 FSHR (0.70) FSHRMEN1ADRB2KMT2ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1406628-A1 TETRAHYDROQUINOLINE DERIVATIVES Akzo Nobel N.V. (NL) 2004-04-14 EP disclosed
WO-2003004028-A1 TETRAHYDROQUINOLINE DERIVATIVES AKZO NOBEL N.V. (NL) 2003-01-16 WO disclosed