Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.64 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3693500 | 0.90 | PDE4A (0.56) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7856722 | 0.90 | TNF (0.56) | PDE4APDE4BPDE4DPDE4CTNF | |
| SCHEMBL7846184 | 0.85 | PDE4A (0.60) | PDE4APDE4BPDE4DPDE4CTNF | |
| SCHEMBL7846671 | 0.85 | TNF (0.49) | PDE4APDE4BPDE4DPDE4CTNF | |
| SCHEMBL7846673 | 0.83 | PDE4B (0.51) | PDE4APDE4BPDE4DPDE4CTNF | |
| SCHEMBL4637301 | 0.81 | PDE4A (0.50) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL3692514 | 0.80 | PDE4A (0.53) | PDE4APDE4BPDE4DPDE4CTNF | |
| SCHEMBL825934 | 0.79 | TNF (0.48) | PDE4APDE4BPDE4DPDE4CTNF | |
| SCHEMBL4637167 | 0.78 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CTNF | |
| SCHEMBL8779410 | 0.78 | TNF (0.49) | PDE4APDE4BPDE4DPDE4CTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874819-B1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORP (US) | 2004-05-26 | — | — | EP | disclosed |
| EP-1035848-A4 | SUBSTITUTED ALKANOHYDROXAMIC ACIDS AND METHOD OF REDUCING TNF-ALPHA LEVELS | CELGENE CORP (US) | 2001-05-23 | — | — | EP | disclosed |
| EP-1035848-A1 | SUBSTITUTED ALKANOHYDROXAMIC ACIDS AND METHOD OF REDUCING TNF-ALPHA LEVELS | CELGENE CORPORATION (US) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999006041-A1 | SUBSTITUTED ALKANOHYDROXAMIC ACIDS AND METHOD OF REDUCING TNFα LEVELS | CELGENE CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |
| US-5728844-A | INHIBITORS OF TUMOR NECROSIS AND PHOSPHODIESTERASE | CELGENE CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |