Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 3/20 | 0.46 |
| ▸ | MDM4 | O15151 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30216574 | 1.00 | MDM2 (0.46) | MDM2MDM4TP53CASP3FABP5 | |
| SCHEMBL16057913 | 1.00 | MDM2 (0.46) | MDM2MDM4TP53CASP3FABP5 | |
| SCHEMBL3346436 | 0.85 | KMT2A (0.42) | MDM2MDM4TP53CASP3FABP5 | |
| SCHEMBL28989642 | 0.84 | KMT2A (0.40) | MDM2CASP3FABP5KMT2AMEN1 | |
| SCHEMBL17094832 | 0.82 | KMT2A (0.40) | MDM2CASP3FABP5KMT2AMEN1 | |
| SCHEMBL12555211 | 0.82 | KMT2A (0.47) | MDM2MDM4TP53CASP3FABP5 | |
| SCHEMBL28031977 | 0.80 | NPC1 (0.50) | MDM2MDM4TP53CASP3FABP5 | |
| SCHEMBL8410923 | 0.79 | KMT2A (0.45) | MDM2MDM4TP53CASP3FABP5 | |
| SCHEMBL17192730 | 0.79 | KMT2A (0.45) | MDM2MDM4TP53CASP3FABP5 | |
| SCHEMBL4395836 | 0.79 | KMT2A (0.45) | MDM2MDM4TP53CASP3FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402268-A2 | CHEMICAL CAPTURE REAGENT | Amersham Biosciences UK Limited (GB) | 2004-03-31 | — | — | EP | disclosed |
| WO-2003005026-A2 | CHEMICAL CAPTURE REAGENT | AMERSHAM BIOSCIENCES UK LIMITED (GB) | 2003-01-16 | — | — | WO | disclosed |
| WO-1996000391-A1 | METHODS FOR THE SYNTHESIS OF DIKETOPIPERAZINES | AFFYMAX TECHNOLOGIES N.V. (AN) | 1996-01-04 | — | — | WO | disclosed |