Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 19/20 | 0.71 |
| ▸ | CCR3 | P51677 | 19/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.68 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6570642 | 0.91 | HRH1 (0.80) | HRH1CCR3KCNH2HRH3 | |
| SCHEMBL6568469 | 0.89 | HRH1 (0.71) | HRH1CCR3KCNH2HRH3 | |
| SCHEMBL5411458 | 0.89 | HRH1 (0.84) | HRH1CCR3KCNH2 | |
| SCHEMBL5415369 | 0.87 | HRH1 (0.71) | HRH1CCR3KCNH2 | |
| SCHEMBL18841156 | 0.84 | CCR3 (0.67) | HRH1CCR3KCNH2HRH3 | |
| SCHEMBL6570388 | 0.83 | HRH1 (0.80) | HRH1CCR3KCNH2 | |
| SCHEMBL18841195 | 0.83 | HRH1 (1.00) | HRH1CCR3KCNH2 | |
| SCHEMBL5410262 | 0.83 | CCR3 (0.81) | HRH1CCR3KCNH2 | |
| SCHEMBL4718927 | 0.83 | HRH1 (0.72) | HRH1CCR3KCNH2 | |
| SCHEMBL6569067 | 0.82 | CCR3 (0.62) | HRH1CCR3KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404667-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003004487-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |