Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.64 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | IDH1 | O75874 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4342071 | 0.87 | EPHX2 (0.68) | EPHX2MAPTNPC1RAB9AFAAH | |
| SCHEMBL12584976 | 0.85 | EPHX2 (0.83) | EPHX2MAPTNPC1RAB9AFAAH | |
| SCHEMBL6568524 | 0.81 | CXCR2 (0.77) | CXCR2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26156260 | 0.80 | EPHX2 (0.69) | EPHX2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11555827 | 0.80 | EPHX2 (1.00) | EPHX2MAPTNPC1RAB9AFAAH | |
| SCHEMBL6567616 | 0.78 | CXCR2 (0.73) | EPHX2CXCR2MAPTNPC1RAB9A | |
| SCHEMBL5605320 | 0.78 | CXCR2 (1.00) | EPHX2CXCR2MAPTNPC1RAB9A | |
| SCHEMBL17079593 | 0.77 | EPHX2 (0.69) | EPHX2MAPTNPC1RAB9AFAAH | |
| SCHEMBL18031167 | 0.77 | EPHX2 (0.86) | EPHX2MAPTNPC1RAB9AFAAH | |
| SCHEMBL4348609 | 0.77 | EPHX2 (0.64) | EPHX2MAPTNPC1RAB9AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |