Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 16/20 | 0.74 |
| ▸ | ITGB2 | P05107 | 14/20 | 0.74 |
| ▸ | ICAM1 | P05362 | 14/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202872 | 1.00 | ITGAL (0.74) | ITGALITGB2ICAM1ALDH1A1RAB9A | |
| SCHEMBL6197445 | 0.85 | ITGAL (1.00) | ITGALITGB2ICAM1CCNCCDK8 | |
| SCHEMBL6567335 | 0.84 | ITGAL (0.80) | ITGALITGB2ICAM1CCNCCDK8 | |
| SCHEMBL6199411 | 0.84 | ITGAL (0.80) | ITGALITGB2ICAM1CCNCCDK8 | |
| SCHEMBL6198436 | 0.84 | ITGAL (0.81) | ITGALITGB2ICAM1 | |
| SCHEMBL6197411 | 0.83 | ITGAL (0.83) | ITGALITGB2ICAM1ALDH1A1RAB9A | |
| SCHEMBL6196591 | 0.81 | ITGAL (0.79) | ITGALITGB2ICAM1ALDH1A1RAB9A | |
| SCHEMBL6199344 | 0.80 | ITGB2 (0.68) | ITGALITGB2ICAM1ALDH1A1KDM4E | |
| SCHEMBL6310329 | 0.80 | ITGAL (0.78) | ITGALITGB2ICAM1CCNCCDK8 | |
| SCHEMBL6569807 | 0.80 | ITGAL (0.79) | ITGALITGB2ICAM1CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481968-A2 | Cell adhesion-inhibiting anti-inflammatory and immune-suppressive compounds | Abbott Laboratories (US) | 2004-12-01 | — | — | EP | disclosed |
| EP-1165505-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059880-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-10-12 | — | — | WO | disclosed |