Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 8/20 | 0.73 |
| ▸ | MAOB | P27338 | 4/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.73 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | BCHE | P06276 | 3/20 | 0.70 |
| ▸ | ACHE | P22303 | 2/20 | 0.70 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.70 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.70 |
| ▸ | MAOA | P21397 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | F3 | P13726 | 2/20 | 0.67 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656920 | 1.00 | CYP1B1 (0.73) | CYP1B1MAOBMAPTTNFRSF1AMEN1 | |
| Chalcone SCHEMBL28350529 | 0.95 | CYP1B1 (0.79) | CYP1B1MAOBMAPTTNFRSF1AMEN1 | |
| SCHEMBL659631 | 0.93 | CYP3A4 (0.73) | CYP1B1MAOBMAPTTNFRSF1AMEN1 | |
| SCHEMBL659632 | 0.93 | CYP3A4 (0.73) | CYP1B1MAOBMAPTTNFRSF1AMEN1 | |
| SCHEMBL25194675 | 0.91 | MAPT (0.73) | CYP1B1MAOBMAPTTNFRSF1AMEN1 | |
| SCHEMBL2664959 | 0.91 | MAPT (0.73) | CYP1B1MAOBMAPTTNFRSF1AMEN1 | |
| SCHEMBL8155008 | 0.89 | TNFRSF1A (0.71) | CYP1B1MAOBMAPTTNFRSF1AMEN1 | |
| SCHEMBL8155004 | 0.89 | TNFRSF1A (0.71) | CYP1B1MAOBMAPTTNFRSF1AMEN1 | |
| SCHEMBL7194844 | 0.89 | TNFRSF1A (0.71) | CYP1B1MAOBMAPTTNFRSF1AMEN1 | |
| SCHEMBL7194840 | 0.89 | TNFRSF1A (0.71) | CYP1B1MAOBMAPTTNFRSF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-B1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIV SAARLAND (DE) | 2016-01-27 | — | — | EP | disclosed |
| US-8912186-B2 | Allosteric protein kinase modulators | UNIVERSITAET DES SAARLANDES (DE) | 2014-12-16 | — | — | US | disclosed |
| US-20120046307-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2012-02-23 | — | — | US | disclosed |
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |
| EP-2177510-A1 | Allosteric protein kinase modulators | Universität des Saarlandes (DE) | 2010-04-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046307-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | AURKC, AURKA, AURKB | CYP1B1 4714/4885MAOB 4512/4885MAPT 964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.