Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.46 |
| ▸ | LPAR3 | Q9UBY5 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.41 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568362 | 0.91 | HDAC3 (0.48) | SMN1; SMN2ALDH1A1KDM4EASAH1ACER2 | |
| SCHEMBL6569529 | 0.89 | LPAR1 (0.46) | LPAR1LPAR3SMN1; SMN2ALDH1A1PLA2G4A | |
| SCHEMBL6570139 | 0.88 | LPAR1 (0.47) | LPAR1LPAR3ALDH1A1PLA2G4AASAH1 | |
| SCHEMBL6568701 | 0.88 | LPAR3 (0.56) | LPAR1LPAR3ALDH1A1PLA2G4AASAH1 | |
| SCHEMBL6570354 | 0.87 | LPAR3 (0.58) | LPAR1LPAR3ALDH1A1PLA2G4AASAH1 | |
| SCHEMBL6569341 | 0.87 | LPAR3 (0.58) | LPAR1LPAR3ALDH1A1PLA2G4AASAH1 | |
| SCHEMBL6569383 | 0.87 | LPAR3 (0.58) | LPAR1LPAR3ALDH1A1PLA2G4AASAH1 | |
| SCHEMBL7618294 | 0.87 | LPAR3 (0.58) | LPAR1LPAR3ALDH1A1PLA2G4AASAH1 | |
| SCHEMBL6568705 | 0.87 | LPAR3 (0.58) | LPAR1LPAR3ALDH1A1PLA2G4AASAH1 | |
| SCHEMBL6570288 | 0.87 | LPAR3 (0.58) | LPAR1LPAR3ALDH1A1PLA2G4AASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1156054-B1 | DRUGS CONTAINING PHOSPHORIC ACID DERIVATIVES AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2004-04-14 | — | — | EP | claimed |
| US-6495533-B1 | TUMOR NECROSIS FACTOR INHIBITORS; RHEUMATOID ARTHRITIS, ULCERATIVE COLITIS, CROHN'S DISEASE, HEPATITIS, SEPSIS, HEMORRHAGIC SHOCK, MULTIPLE SCLEROSIS, CEREBRAL INFARCTION, DIABETES, INTERSTITIAL PNEUMONIA, PAIN, HIV | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-12-17 | — | — | US | claimed |
| EP-1156054-A1 | DRUGS CONTAINING PHOSPHORIC ACID DERIVATIVES AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-11-21 | — | — | EP | claimed |