SCHEMBL6570283

SCHEMBL6570283

O=C1CC(c2ccccc2Cl)C(c2ccccc2Cl)C1

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.60
RECQL P46063 1/20 0.60
DPP4 P27487 4/20 0.53
SLC6A3 Q01959 5/20 0.49
HTR2A P28223 1/20 0.47
HTR2C P28335 1/20 0.47
HTR2B P41595 1/20 0.47
SLC6A2 P23975 5/20 0.46
SMN1; SMN2 Q16637 2/20 0.44
SLC9A1 P19634 1/20 0.44
ALDH1A1 P00352 2/20 0.41
KDM4E B2RXH2 1/20 0.41
HPGD P15428 1/20 0.41
TSHR P16473 1/20 0.41
HSD17B10 Q99714 1/20 0.41
TNKS2 Q9H2K2 1/20 0.41
LDHA P00338 1/20 0.40
LDHB P07195 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6570333 1.00 TP53 (0.60) TP53RECQLDPP4SLC6A3HTR2A
SCHEMBL6570278 1.00 TP53 (0.60) TP53RECQLDPP4SLC6A3HTR2A
SCHEMBL427764 0.83 TP53 (0.85) TP53RECQLDPP4SLC6A3SMN1; SMN2
SCHEMBL13036866 0.78 TP53 (0.55) TP53RECQLDPP4SLC6A3HTR2A
SCHEMBL30383571 0.78 TP53 (0.55) TP53RECQLDPP4SLC6A3HTR2A
SCHEMBL11970977 0.78 TP53 (0.55) TP53RECQLDPP4SLC6A3SLC6A2
SCHEMBL11970980 0.78 TP53 (0.55) TP53RECQLDPP4SLC6A3SLC6A2
SCHEMBL7002501 0.76 DPP4 (0.66) DPP4SLC6A3HTR2AHTR2CHTR2B
SCHEMBL8144699 0.76 DPP4 (0.66) DPP4SLC6A3HTR2AHTR2CHTR2B
SCHEMBL30052677 0.76 DPP4 (0.66) DPP4SLC6A3HTR2AHTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1280811-B1 HYDROFORMYLATION METHOD, BRIDGED COMPOUNDS OF PHOSPHORUS, ARSENIC AND ANTIMONY AND CATALYST COMPRISING A COMPLEX OF SAID BRIDGED COMPOUNDS BASF AG (DE) 2004-10-13 EP disclosed
EP-1280811-A1 HYDROFORMYLATION METHOD, BRIDGED COMPOUNDS OF PHOSPHORUS, ARSENIC AND ANTIMONY AND CATALYST COMPRISING A COMPLEX OF SAID BRIDGED COMPOUNDS BASF AKTIENGESELLSCHAFT (DE) 2003-02-05 EP disclosed
WO-2001085739-A1 HYDROFORMYLATION METHOD, BRIDGED COMPOUNDS OF PHOSPHORUS, ARSENIC AND ANTIMONY AND CATALYST COMPRISING A COMPLEX OF SAID BRIDGED COMPOUNDS BASF AKTIENGESELLSCHAFT (DE) 2001-11-15 WO disclosed