Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | SMO | Q99835 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6570486 | 0.81 | MAPK14 (0.51) | MAPK14BRAFRAF1SMO | |
| SCHEMBL6532402 | 0.78 | MAPK14 (0.67) | MAPK14KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL27497710 | 0.73 | MAPK14 (0.46) | MAPK14KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL27515238 | 0.73 | MAPK14 (0.44) | MAPK14KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL13198146 | 0.72 | MAPK14 (0.61) | MAPK14KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL13198153 | 0.71 | MAPK14 (0.55) | MAPK14KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL5897054 | 0.71 | MAPK14 (0.65) | MAPK14KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL13198161 | 0.70 | MAPK14 (0.53) | MAPK14KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL13198154 | 0.70 | MAPK14 (0.61) | MAPK14KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL13198140 | 0.70 | NR1H4 (0.64) | MAPK14KDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-B1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 2004-11-17 | — | — | EP | disclosed |