SCHEMBL6570508

SCHEMBL6570508

Cc1c(CCl)[nH]c(=O)[nH]c1=O

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TYMP P19971 16/20 0.46
L3MBTL1 Q9Y468 1/20 0.37
ALOX15 P16050 1/20 0.32
ATAD2 Q6PL18 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30132270 0.77 TYMP (0.52) TYMPL3MBTL1ALOX15ATAD2
SCHEMBL25344146 0.77 TYMP (0.46) TYMPL3MBTL1ALOX15ATAD2
SCHEMBL14709896 0.76 TYMP (0.47) TYMPL3MBTL1ATAD2
SCHEMBL6060121 0.74 TYMP (0.52) TYMP
SCHEMBL9007002 0.74 TYMP (0.43) TYMPL3MBTL1ALOX15ATAD2
SCHEMBL6573862 0.73 TYMP (0.57) TYMP
SCHEMBL6574092 0.73 TYMP (0.50) TYMP
SCHEMBL7074796 0.72 TYMP (0.42) TYMPL3MBTL1ALOX15
SCHEMBL4315838 0.71 KDM4E (0.43) TYMPL3MBTL1
SCHEMBL14478237 0.71 TYMP (0.45) TYMPL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019049174-A1 SOLID STATE FORMS OF 5-CHLORO-6-[(2-IMINOPYRROLIDIN-1-YL)METHYL]PYRIMIDINE-2,4-(1H,3H)-DIONE HYDROCHLORIDE AND THEIR PROCESSES FOR THE PREPARATION THEREOF MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) 2019-03-14 WO disclosed
EP-0884051-B1 CANCEROUS METASTASIS INHIBITORS CONTAINING URACIL DERIVATIVES TAIHO PHARMACEUTICAL CO LTD (JP) 2004-12-15 EP disclosed
EP-0763529-B1 URACIL DERIVATIVES, AND ANTITUMOR EFFECT POTENTIATOR AND ANTITUMOR AGENT CONTAINING THE SAME TAIHO PHARMACEUTICAL CO LTD (JP) 2003-07-23 EP disclosed
US-6294535-B1 TREATING CANCER, WHICH COMPRISES ADMINISTERING TO A PATIENT IN NEED OF TREATMENT AN EFFECTIVE AMOUNT OF A URACIL DERIVATIVE TAIHO PHARMACEUTICAL CO., LTD. (JP) 2001-09-25 US disclosed
US-6255314-B1 Cancerous metastasis inhibitors containing uracil derivatives TAIHO CHARMACEUTICAL CO., LTD. (JP) 2001-07-03 US disclosed
US-6159969-A Uracil derivatives, and antitumor effect potentiator and antitumor agent containing the same TAIHO PHARMACEUTICAL CO., LTD. (JP) 2000-12-12 US disclosed
EP-0884051-A1 CANCEROUS METASTASIS INHIBITORS CONTAINING URACIL DERIVATIVES TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) 1998-12-16 EP disclosed
US-5744475-A 4-N-HET-METHYLURACIL DERIVATIVES; THYMIDINE PHOSPHORYLASE INHIBITORS TAIHO PHARMACEUTICAL CO., LTD. (JP) 1998-04-28 US disclosed
EP-0763529-A1 URACIL DERIVATIVES, AND ANTITUMOR EFFECT POTENTIATOR AND ANTITUMOR AGENT CONTAINING THE SAME TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) 1997-03-19 EP disclosed