SCHEMBL6571478

SCHEMBL6571478

CCc1cc(Oc2cccc(C(NCC(O)C(F)(F)F)c3ccc(C(F)(F)F)cc3F)c2)ccc1Cl

nearest known ligand 0.59

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CETP P11597 8/20 0.59
PDE2A O00408 2/20 0.40
TLR8 Q9NR97 1/20 0.37
TLR7 Q9NYK1 1/20 0.37
HTR2A P28223 4/20 0.36
SLC6A4 P31645 4/20 0.36
KCNH2 Q12809 4/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
CASR P41180 1/20 0.35
ALDH1A1 P00352 1/20 0.34
CTDSP1 Q9GZU7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6568317 1.00 CETP (0.59) CETPPDE2ATLR8TLR7HTR2A
SCHEMBL6571560 0.93 CETP (0.60) CETPTLR8TLR7HTR2ASLC6A4
SCHEMBL6568883 0.93 CETP (0.60) CETPTLR8TLR7HTR2ASLC6A4
SCHEMBL6570310 0.89 CETP (0.45) CETPPDE2ATLR8TLR7HTR2A
SCHEMBL6435457 0.87 CETP (0.42) CETPPDE2A
SCHEMBL6063930 0.87 CETP (0.42) CETPPDE2A
SCHEMBL994517 0.86 CETP (0.41) CETPPDE2ATLR8TLR7HTR2A
SCHEMBL6274625 0.86 CETP (0.41) CETPPDE2ATLR8TLR7HTR2A
SCHEMBL5671276 0.86 CETP (0.40) CETPPDE2ATLR8TLR7KCNH2
SCHEMBL1899039 0.86 PDE2A (0.42) CETPPDE2ACASRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1469831-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING A SOLID AMORPHOUS DISPERSION OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS Pfizer Products Inc. (US) 2004-10-27 EP disclosed
WO-2003063832-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING A SOLID AMORPHOUS DISPERSION OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS PFIZER PRODUCTS INC. (US) 2003-08-07 WO disclosed