SCHEMBL6571893

SCHEMBL6571893

CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(Cl)c(Cl)c1

nearest known ligand 0.78

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 8/20 0.78
CACNA1F O60840 1/20 0.78
CHRM2 P08172 1/20 0.78
ACHE P22303 1/20 0.78
AGTR1 P30556 1/20 0.78
DRD3 P35462 1/20 0.78
CACNA1D Q01668 1/20 0.78
CACNA1S Q13698 1/20 0.78
CACNA1C Q13936 1/20 0.78
CYP1A2 P05177 1/20 0.71
CYP3A4 P08684 1/20 0.71
CYP2D6 P10635 1/20 0.71
CYP2C9 P11712 1/20 0.71
MAPK1 P28482 1/20 0.71
CYP2C19 P33261 1/20 0.71
GRIN1 Q05586 1/20 0.58
GRIN2B Q13224 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6573634 0.99 KCNH2 (0.77) KCNH2CACNA1FCHRM2ACHEAGTR1
Dofetilide SCHEMBL6102734 0.88 KCNH2 (1.00) KCNH2CACNA1FCHRM2ACHEAGTR1
Dofetilide SCHEMBL16135 0.88 KCNH2 (1.00) KCNH2CACNA1FCHRM2ACHEAGTR1
Dofetilide SCHEMBL8362214 0.87 KCNH2 (0.97) KCNH2CACNA1FCHRM2ACHEAGTR1
SCHEMBL9053008 0.83 KCNH2 (0.77) KCNH2CACNA1FCHRM2ACHEAGTR1
SCHEMBL9655059 0.83 KCNH2 (1.00) KCNH2CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL29625252 0.83 KCNH2 (1.00) KCNH2CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL4203444 0.83 KCNH2 (1.00) KCNH2CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL24600680 0.83 KCNH2 (0.88) KCNH2CACNA1FCHRM2ACHEAGTR1
SCHEMBL9628071 0.83 KCNH2 (0.88) KCNH2CACNA1FCHRM2ACHEAGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0775689-B9 NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC C & C RES LABS (KR) 2004-09-15 EP claimed
EP-0775689-B1 NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC C & C RES LABS (KR) 2003-09-03 EP claimed
US-6057358-A POTASSIUM CHANNEL BLOCKING ANTIARRHYTHMIC DRUGS WITH LESS SIDE EFFECTS C&C RESEARCH LABS. (KR) 2000-05-02 US claimed
EP-0775689-A1 NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC C & C RESEARCH LABS. (KR) 1997-05-28 EP claimed