Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.62 |
| ▸ | GRIA1 | P42261 | 7/20 | 0.53 |
| ▸ | CHRND | Q07001 | 5/20 | 0.53 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.53 |
| ▸ | CHRNG | P07510 | 1/20 | 0.53 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6571434 | 1.00 | PTPN1 (0.62) | PTPN1GRIA1CHRNDCHRNA1CHRNG | |
| SCHEMBL6571438 | 1.00 | PTPN1 (0.62) | PTPN1GRIA1CHRNDCHRNA1CHRNG | |
| SCHEMBL6575066 | 0.99 | PTPN1 (0.61) | PTPN1GRIA1CHRNDCHRNA1CHRNG | |
| SCHEMBL6575070 | 0.99 | PTPN1 (0.61) | PTPN1GRIA1CHRNDCHRNA1CHRNG | |
| SCHEMBL6571404 | 0.99 | PTPN1 (0.61) | PTPN1GRIA1CHRNDCHRNA1CHRNG | |
| SCHEMBL6571396 | 0.99 | PTPN1 (0.61) | PTPN1GRIA1CHRNDCHRNA1CHRNG | |
| SCHEMBL6574908 | 0.95 | PTPN1 (0.66) | PTPN1GRIA1CHRNDCHRNB2CHRNB4 | |
| SCHEMBL6571541 | 0.95 | PTPN1 (0.59) | PTPN1GRIA1CHRNDCHRNA1CHRNG | |
| SCHEMBL6572536 | 0.95 | PTPN1 (0.56) | PTPN1GRIA1CHRNDCHRNA1CHRNG | |
| SCHEMBL6572533 | 0.95 | PTPN1 (0.56) | PTPN1GRIA1CHRNDCHRNA1CHRNG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6353023-B1 | AROMATIC COMPOUNDS WITH AMIDE GROUPS | PHARMACIA & UPJOHN COMPANY | 2002-03-05 | — | — | US | claimed |
| EP-1019364-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-19 | — | — | EP | claimed |
| WO-1999011606-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 1999-03-11 | — | — | WO | claimed |
| EP-1019364-B1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | BIOVITRUM AB (SE) | 2004-06-09 | — | — | EP | disclosed |
| US-6410585-B1 | THERAPY FOR NON-INSULIN DEPEND DIABETES | BIOVITRUM AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6353023-B1 | AROMATIC COMPOUNDS WITH AMIDE GROUPS | PHARMACIA & UPJOHN COMPANY | 2002-03-05 | — | — | US | disclosed |
| EP-1019364-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999011606-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 1999-03-11 | — | — | WO | disclosed |