Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 3/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6571551 | 0.96 | S1PR1 (0.40) | S1PR1S1PR3ITGB3ITGA2BPPARA | |
| SCHEMBL6575641 | 0.89 | S1PR1 (0.43) | S1PR1S1PR3ITGB3ITGA2BPPARA | |
| SCHEMBL6574703 | 0.87 | S1PR1 (0.39) | S1PR1S1PR3ITGB3ITGA2BPPARA | |
| SCHEMBL6571345 | 0.87 | S1PR1 (0.39) | S1PR1S1PR3ITGB3ITGA2BPPARA | |
| SCHEMBL8115628 | 0.83 | S1PR1 (0.41) | S1PR1S1PR3ITGB3ITGA2BPPARA | |
| SCHEMBL6573631 | 0.81 | S1PR1 (0.41) | S1PR1S1PR3ITGB3ITGA2BPPARA | |
| Aspartic Acid SCHEMBL7363750 | 0.68 | SLC7A5 (0.53) | ITGB3ITGA2BPPARAALDH1A1SMN1; SMN2 | |
| Aspartic Acid SCHEMBL7363742 | 0.68 | SLC7A5 (0.53) | ITGB3ITGA2BPPARAALDH1A1SMN1; SMN2 | |
| SCHEMBL4481943 | 0.67 | ALPI (0.42) | MMP1MMP2LTA4H | |
| SCHEMBL10528446 | 0.66 | BIRC2 (0.41) | MMP1MMP2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019364-B1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | BIOVITRUM AB (SE) | 2004-06-09 | — | — | EP | disclosed |
| US-6410585-B1 | THERAPY FOR NON-INSULIN DEPEND DIABETES | BIOVITRUM AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6353023-B1 | AROMATIC COMPOUNDS WITH AMIDE GROUPS | PHARMACIA & UPJOHN COMPANY | 2002-03-05 | — | — | US | disclosed |
| EP-1019364-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999011606-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | PHARMACIA & UPJOHN COMPANY (US) | 1999-03-11 | — | — | WO | disclosed |