Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.78 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.78 |
| ▸ | MAOB | P27338 | 3/20 | 0.78 |
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.78 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.78 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | BCHE | P06276 | 2/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.68 |
| ▸ | RELA | Q04206 | 1/20 | 0.68 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.67 |
| ▸ | F3 | P13726 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL657323 | 1.00 | MEN1 (0.78) | MEN1KMT2ACYP1B1MAOBMAPT | |
| SCHEMBL5888213 | 0.90 | CYP1B1 (0.73) | MEN1KMT2ACYP1B1MAOBMAPT | |
| SCHEMBL21122057 | 0.90 | CYP1B1 (0.73) | MEN1KMT2ACYP1B1MAOBMAPT | |
| 4'-Methoxychalcone SCHEMBL521905 | 0.88 | MAOB (1.00) | MEN1KMT2ACYP1B1MAOBMAPT | |
| 4'-Methoxychalcone SCHEMBL1675978 | 0.88 | MAOB (1.00) | MEN1KMT2ACYP1B1MAOBMAPT | |
| SCHEMBL21679509 | 0.87 | MAOB (0.78) | MEN1KMT2ACYP1B1MAOBMAPT | |
| SCHEMBL21679508 | 0.87 | MAOB (0.78) | MEN1KMT2ACYP1B1MAOBMAPT | |
| SCHEMBL29869351 | 0.87 | MAOB (0.78) | MEN1KMT2ACYP1B1MAOBMAPT | |
| SCHEMBL8987072 | 0.87 | MAOB (1.00) | MEN1KMT2ACYP1B1MAOBMAPT | |
| SCHEMBL8987069 | 0.87 | MAOB (1.00) | MEN1KMT2ACYP1B1MAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-B1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIV SAARLAND (DE) | 2016-01-27 | — | — | EP | disclosed |
| US-8912186-B2 | Allosteric protein kinase modulators | UNIVERSITAET DES SAARLANDES (DE) | 2014-12-16 | — | — | US | disclosed |
| US-20120046307-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2012-02-23 | — | — | US | disclosed |
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |
| EP-2177510-A1 | Allosteric protein kinase modulators | Universität des Saarlandes (DE) | 2010-04-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046307-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | AURKC, AURKA, AURKB | MEN1 2058/4885KMT2A 1777/4885CYP1B1 4714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.